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We treated 22 patients with subacute sclerosing panencephalitis(SSPE)with intraventricular x-interferon(IFN)and inosiplex PO and followed them for 2 to 54 months.Three deaths occurred.Clinical improvement,demonstrated by decreasing scores on the Neurological Disability Index,occurred in 11/22 (50%);five patients became stable,and the progression rate of the disease decreased in three.The remission rate was significantly higher than untreated controls from the same institution.Patients who had a slowly progressive disease responded best to treatment.Serious side effects were rare.We recommend intraventricular IFN,combined with oral inosiplex,in the treatment of SSPE. |
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